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71.
Speciation of arsenic in ground water samples: A comparative study of CE-UV, HG-AAS and LC-ICP-MS 总被引:1,自引:0,他引:1
The performance of capillary electrophoresis-ultraviolet detector (CE-UV), hydride generation-atomic absorption spectrometry (HG-AAS) and liquid chromatography-inductively coupled plasma mass spectrometry (LC-ICP-MS) have been compared for the speciation of arsenic (As) in groundwater samples. Two inorganic As species, arsenite (AsIII), arsenate (AsV) and one organo species dimethyl arsenic acid (DMA) were mainly considered for this study as these are known to be predominant in water. Under optimal analytical conditions, limits of detection (LD) ranging from 0.10 (AsIII, AsT) to 0.19 (DMA) μg/l for HG-AAS, 100 (AsIII, DMA) to 500 (AsV) μg/l for CE-UV and 0.1 (DMA, MMA) to 0.2 (AsIII, AsV) μg/l for LC-ICP-MS, allowed the determination of the above three species present in these samples. Results obtained by all the three methods are well correlated (r2 = 0.996*** for total As) with the precision of <5% R.S.D. except CE-UV. The effect of interfering ions (e.g. Fe2+, Fe3+, SO42− and Cl−) commonly found in ground water on separation and estimation of As species were studied and corrected for. Spike recovery was tested and found to be 80-110% at 0.5 μg/l As standard except CE-UV where only 50% of the analyte was recovered. Comparison of these results shows that LC-ICP-MS is the best choice for routine analysis of As species in ground water samples. 相似文献
72.
Kuriakose J Ghosh A Ravi Kumar V Kulkarni BD 《The Journal of chemical physics》2004,120(11):5432-5443
Heterogeneous surface reactions exhibiting complex spatiotemporal dynamics and patterns can be studied as processes involving reaction-diffusion mechanisms. In many realistic situations, the surface has fractal characteristics. This situation is studied by isometric graphing and multidimensional scaling (IGMDS) of fractal surfaces for extracting geodesic distances (i.e., shortest scaled distances that obtain edges of neighboring surface nodes and their interconnections) and the results obtained used to model effects of surface diffusion with nonlinear reactions. Further analysis of evolved spatiotemporal patterns may be carried out by IGMDS because high-dimensional snapshot data can be efficiently projected to a transformed subspace with reduced dimensions. Validation of the IGMDS methodology is carried out by comparing results with reduction capabilities of conventional principal component analysis for simple situations of reaction and diffusion on surfaces. The usefulness of the IGMDS methodology is shown for analysis of complex patterns formed on both regular and fractal surfaces, and using generic nonlinear reaction-diffusion systems following FitzHugh Nagumo and cubic reaction kinetics. The studies of these systems with nonlinear kinetics and noise show that effects of surface disorder due to fractality can become very relevant. The relevance is shown by studying properties of dynamical invariants in IGMDS component space, viz., the Lyapunov exponents and the KS entropy for interesting situations of spiral formation and turbulent patterns. 相似文献
73.
A. K. Patra J. Sudhakar P. M. Ravi J. P. James A. G. Hegde M. L. Joshi 《Journal of Radioanalytical and Nuclear Chemistry》2006,270(2):307-312
Summary The activity and absorbed dose rate of the naturally occurring radionuclides, viz. 238U, 232 Th and 40K were determined in soil and rock samples collected around Kaiga site. The mean activity levels (Kaiga soil) of naturally
occurring 232 Th are comparable with that in worldwide soil, while concentrations of 238U and 40K are lower than those in worldwide soil. The absorbed dose rate in outdoor air ranged 20-58 nGy . h-1 with a mean of 33.3 nGy . h-1, which is below the world average of 60 nGy . h-1. The total effective dose rate in outdoor air for soils ranged 25.6-74.4 mSv . y-1 with a mean of 43.0 mSv . y-1. The estimated dose rate at Kaiga is comparable with that estimated at Kakrapar and Rawatbhata and much less than that estimated
at coastal sites of India. 相似文献
74.
Romeiro NC Albuquerque MG de Alencastro RB Ravi M Hopfinger AJ 《Journal of computer-aided molecular design》2005,19(6):385-400
The p38-mitogen-activated protein kinase (p38-MAPK) plays a key role in lipopolysaccharide-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) release during the inflammatory process, emerging as an attractive target for new anti-inflammatory agents. Four-dimensional quantitative structure-activity relationship (4D-QSAR) analysis [Hopfinger et al., J. Am. Chem. Soc., 119 (1997) 10509] was applied to a series of 33 (a training set of 28 and a test set of 5) pyridinyl-imidazole and pyrimidinyl-imidazole inhibitors of p38-MAPK, with IC50 ranging from 0.11 to 2100 nM [Liverton et al., J. Med. Chem., 42 (1999) 2180]. Five thousand conformations of each analogue were sampled from a molecular dynamics simulation (MDS) during 50 ps at a constant temperature of 303 K. Each conformation was placed in a 2 angstroms grid cell lattice for each of three trial alignments. 4D-QSAR models were constructed by genetic algorithm (GA) optimization and partial least squares (PLS) fitting, and evaluated by leave-one-out cross-validation technique. In the best models, with three to six terms, the adjusted cross-validated squared correlation coefficients, Q2adj, ranged from 0.67 to 0.85. Model D (Q2adj = 0.84) was identified as the most robust model from alignment 1, and it is representative of the other best models. This model encompasses new molecular regions as containing pharmacophore sites, such as the amino-benzyl moiety of pyrimidine analogs and the N1-substituent in the imidazole ring. These regions of the ligands should be further explored to identify better anti-inflammatory inhibitors of p38-MAPK. 相似文献
75.
Ming-Chang P. Yeh Chi-Fen Jou Wei-Tzou Yeh Da-Yu Chiu N. Ravi Kumar Reddy 《Tetrahedron》2005,61(2):493-500
Intramolecular 1,3-dipolar cycloaddition of cyclo-1,3-diene- and -1,3,5-triene-tethered nitrile oxides gave tricyclic isoxazolines as a single stereoisomer in most cases. The relative stereochemistry of tricycle-fused isoxazolines resulting from 1,3-dipolar cycloaddition of cyclo-1,3-diene-tethered nitrile oxides is cis-cis, whereas from cyclohepta-1,3,5-triene-tethered nitrile oxides the cis-trans isomer predominates. 相似文献
76.
Hert J Willett P Wilton DJ Acklin P Azzaoui K Jacoby E Schuffenhauer A 《Journal of chemical information and computer sciences》2004,44(3):1177-1185
Fingerprint-based similarity searching is widely used for virtual screening when only a single bioactive reference structure is available. This paper reviews three distinct ways of carrying out such searches when multiple bioactive reference structures are available: merging the individual fingerprints into a single combined fingerprint; applying data fusion to the similarity rankings resulting from individual similarity searches; and approximations to substructural analysis. Extended searches on the MDL Drug Data Report database suggest that fusing similarity scores is the most effective general approach, with the best individual results coming from the binary kernel discrimination technique. 相似文献
77.
Kamal A. Idriss Magda S. Saleh Mohamed M. Seleim Fatma S. Hassan Sherif K. Idriss 《Monatshefte für Chemie / Chemical Monthly》1990,121(8-9):625-634
Summary A simple, rapid, selective, and sensitive method for the spectrophotometric determination of palladium is developed based on the reaction of Pd(II) with 1-amino-4-hydroxyanthraquinone (AMHA). The reaction is carried out atpH 3.8 in 50% (v/v) ethanol-water medium. The molar absorptivity of the complexed ligand is 1.1 · 104 l mol–1 cm–1 at 620 nm. Calibration plots are linear up to 17 µg Pd cm–3. The optimum concentration range (Ringbom plot) is between 3–14.5 µg cm–3. The spectral study of the reaction in solutions containing equimolar concentrations or an excess of one component, in thepH range 0.3–6.5, indicate the possible complex transitions that occur in solution. Complete graphical and logarithmic analysis of the absorbance-pH graphs was performed to demonstrate and characterize the complexation equilibria in solution. Under the optimum conditions, palladium can be determined as the noncharged complex Pd(AMHA)2 in the presence of a large number of foreign ions. Interferences caused by zirconium(IV) could be masked with fluoride ions.
Eine neue spektrophotometrische Methode für die Bestimmung von Palladium in Spuren
Zusammenfassung Eine einfache, schnelle und empfindliche Methode für die spektrophotometrische Bestimmung von Palladium wurde auf der Basis der Reaktion von Pd(II) mit 1-Amino-4-hydroxyanthrachinon (AMHA) entwickelt. Die Reaktion wird in 50% (v/v) Ethanol/Wasser beipH 3.8 ausgeführt. Die molare Absorption des komplexierten Liganden beträgt 1.1 · 104 l mol–1 cm–1 bei 620 nm. Kalibrierungskurven verlaufen bis zu 17 µg Pd cm–3 linear. Der optimale Konzentrationsbereich (Ringbom-Plot) liegt zwischen 3 und 14.5 µg cm–3. Spektroskopische Untersuchungen der Reaktion in Lösungen, entweder mit equimolaren Konzentrationen oder mit einem Überschuß an einer Komponente impH-Bereich 0.3–6.5, lassen Rückschlüsse auf mögliche Komplex-Übergänge in Lösung zu. Es wurde eine vollständige graphische, logarithmische Analyse der Absorptions-pH-Graphen durchgeführt, um die Komplexgleichgewichte in Lösung aufzuklären und zu charakterisieren. Unter den Optimalbedingungen kann Palladium als nichtgeladener Komplex Pd(AMHA)2 in Gegenwart einer großen Anzahl an Fremd-Ionen bestimmt werden. Schwierigkeiten mit Zirkonium(IV) konnte durch Maskierung mit Fluorid-Ionen umgangen werden.相似文献
78.
Parmeswaran D Pushpan SK Srinivasan A Ravi Kumar M Chandrashekar TK Ganesan S 《Photochemistry and photobiology》2003,78(5):487-495
The core modification of expanded porphyrins has been proved to have better photochemical properties, which are favorable for photodynamic therapy (PDT) applications. In this context, this study was aimed to investigate the in vitro and in vivo photodynamic activity of one such core-modified expanded porphyrin, namely, ammonium salt of 5,10,15,20-tetrakis-(meso-p-sulfonato phenyl)-25,27,29-trithia sapphyrin. For the in vitro studies, human erythrocytes were used as a membrane semimodel system to investigate the partitioning ability and drug-uptake characteristics. The partition studies on the membrane semimodel system revealed that maximum partitioning occurs at 12 microgm/mL concentration, and from the drug-uptake studies it is observed that maximum amount of the sensitizer is bound to the erythrocyte membranes during a 45 min incubation period. Photohemolysis studies at different concentrations of the sensitizer and exposure time showed maximum damage at 5 microgm/mL and 30 min exposure time. In vivo studies were performed on 7,12-dimethylbenz(a)nthracene-induced superficial squamous cell carcinoma on mouse skin. The sensitizer at a concentration of 2.5% in 2.0% dimethyl sulfoxide was applied topically on the tumor spot. After 1 h incubation the tumor spot was exposed to laser irradiation from Nd-YAG laser at its second harmonic wavelength of 532 nm. The photodynamic efficacy was estimated by tumor volume measurements at regular intervals after the treatment. One month after PDT exposure a 3.9-fold decrease in the tumor volume was observed with respect to the tumor volume before treatment. The treatment efficacy was further confirmed by histological and fluorescence spectroscopic evaluations of the tissue biopsy sample from the treated area. The results of our study suggest that the ammonium salt of 5,10,15,20-tetrakis-(meso-p-sulfonato phenyl)-25,27,29-trithia sapphyrin may find possible applications in the new modality of cancer treatment. 相似文献
79.
Andrzej Czarnecki A. N. Kamal Qiping Xu 《Zeitschrift fur Physik C Particles and Fields》1992,54(3):411-417
We have analysed the recent data onD→ππ and \(K\bar K\) decays from ARGUS, CLEO and E691. (i) We find that Bauer, Stech and Wirbel (BSW) model does fairly well in explaining all data if we assume that final state interactions simply rotate the amplitudes in the complex plane. However, to get a good fit one needs to raiseD→K transition amplitudes by (5–10)% over the BSW values and lowerD→π amplitudes by a similar amount. (ii) We show that all the data can also be understood in a coupled channel inelastic model. (iii) We also find that the Isgur, Scora, Grinstein and Wise (ISGW) model-form factors, if extrapolated to small momentum transfers (t) by a single pole formula, yield branching ratios too small in comparison to data. We propose an alternate scheme to interpolate between BSW form factors att=0 and ISGW form factors att=t max. 相似文献
80.